Lucentra®

Lucentra® contains a toxin produced by the bacterium Clostridium botulinum. It works by stopping your muscles from contracting. It does this by stopping the release of a chemical that acts between the nerves and muscles which makes the muscles contract. This helps to reduce abnormal muscle contractions known as spasms.

Lucentra® can also be used to prevent the muscle contractions, which cause frown lines and crow’s feet. This muscle relaxation is temporary and gradually wears off. Some people are distressed when lines appear on their faces.

Adults:

Lucentra® is used in adults to treat muscle spasms:

• Around the eyes
• In the face
• In the neck
• In the arms and shoulders
• In the leg

Lucentra® is also used in adults for:

• The temporary improvement in the appearance of moderate to severe glabellar lines (the vertical frown lines between the eyebrows) and lateral canthal lines (crow’s feet lines), in patients under 65 years of age.
• Hyperhidrosis: This is a condition where there is excess sweating of the armpits, which interferes with daily living.

Children:

Lucentra® is used in children with cerebral palsy (aged older than 2 years):

• to treat muscle spasms in the legs and improve walking
• to treat muscle spasms in the arms.

Your doctor will choose your dose of medicine and decide how often you need treatment. This will depend on what you are being treated for. A vial of Lucentra® should be used only for you and only for a single treatment session.

Adults:

For temporary improvement of glabellar lines:
Lucentra® should only be administered by physicians with appropriate qualifications and expertise in this treatment and having the required equipment.
Your doctor will prepare and give the injections. A vial of Lucentra® should be used only for you and only for a single treatment session.

The recommended dose is:

• For glabellar lines: 50 units, injected as 10 units at each of 5 injection sites in your forehead in the area above your nose and eyebrows.
• The units used for different botulinum toxin products are not the same.
• Lucentra® units are not interchangeable with other botulinum toxin products.
• The effect of the treatment should be noticeable within a few days after injection.
• The scheduling of Lucentra® treatments will be personalized and decided by your doctor based on your specific needs.
• You should not have treatment more often than every 12 weeks.

Lucentra® is a lyophilized powder for solution for injection. It appears as a white powder in a glass vial. Each box of Lucentra® contains one vial of Lucentra®, one Normal Saline 5 mL vial for injectable solution preparation, and one patient leaflet.

• A fast-acting, long-lasting treatment
• A natural-looking boost, but not a frozen look
• A convenient way to feel a beautiful boost, but not a total transformation
• Widespread use in large muscle areas
• Effective and well-tolerated muscle relaxation
• A well-characterized safety profile
• A convenient way to provide relief from muscle stiffness and associated pain

• Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date, which is stated on the label after ‘EXP’. The expiry date refers to the last day of that month. Store in a refrigerator (+2°C to +8°C). Do not freeze.
• Chemical and physical in-use stability has been demonstrated for the reconstituted solution for 24 hours in a refrigerator (+2°C to +8°C). After the solution is made up, unless the method of reconstitution precludes the risk of microbial contamination, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user.
• Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

There are increased risks of having Lucentra® injections under any of these circumstances.
Talk to your doctor, pharmacist or nurse before using Lucentra® if:

• You have problems swallowing
• You have any history of bronchitis, pneumonia or problems with breathing
• You have had an allergic reaction to a botulinum toxin in the past
• You have other problems or diseases that affect your muscles e.g. myasthenia gravis
• You bleed easily
• You have an infection where the injection is given or if that area is swollen
• The muscles at the proposed site of injection are weak or show signs of wasting.
• You have had surgery on your face, or are likely to undergo facial surgery or other types of surgery soon (if you are considering treatment for glabellar lines or lateral canthal lines)
• You had no significant improvement of your lines after your last treatment (if you are considering treatment for glabellar lines or lateral canthal lines).

When Lucentra® is used to treat persistent muscle spasms in the eyelid and face, or to improve the appearance of glabellar and/or and crow’s feet lines, your eyes may become dry. Lucentra® may make your eyes blink less often or produce fewer tears, which could harm the surface of your eyes.

Children and adolescents:

For the treatment of spasticity associated with cerebral palsy in children, Lucentra® should only be used in children older than 2 years. Lucentra® is not indicated for the treatment of glabellar lines and lateral canthal lines in patients under the age of 18 years.